EVALUATION OF AN IN-VITRO DISSOLUTION AND PERMEATION APPARATUS FOR ORAL SOLID PHARMACEUTICAL DOSAGE FORMS

An apparatus based in the USP dissolution test, the F-C-SL apparatus ( Ferreira-Costa-Sousa Lobo), was developed that allowed the simultaneou s evaluation of the in vitro release and permeation of oral solid phar maceutical dosage forms. The release rate in both dissolution devices (USP and F-C-SL apparatus) was evaluated with acetaminophen tablets. D ifferent test conditions (stirring rate and solvent volume ratio) were investigated and no significant differences in acetaminophen release rate were found between these apparatuses. In the F-C-SL apparatus, th e in vitro permeation kinetics of acetaminophen were evaluated using s ynthetic membranes and followed a zero-order kinetic.