NEW PYRROLE DERIVATIVES .9. FORMATION AND CYCLIZATION OF 2-ACYLAMINO-1H-PYRROLO-3,4-DICARBONITRILES

Authors
EBENRETH A BOHM R PECH R
Citation
A. Ebenreth et al., NEW PYRROLE DERIVATIVES .9. FORMATION AND CYCLIZATION OF 2-ACYLAMINO-1H-PYRROLO-3,4-DICARBONITRILES, Archiv der pharmazie, 326(5), 1993, pp. 303-305
Citations number
9
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
326
Issue
5
Year of publication
1993
Pages
303 - 305
Database
ISI
SICI code
0365-6233(1993)326:5<303:NPD.FA>2.0.ZU;2-I
Abstract
2-Acylaminopyrrole-3,4-dicarbonitriles 3a-f were prepared from the cor responding diamides 2a-f by treatment with POCl3/N)V-dimethylaniline a t 40-degrees-C.- By reaction with P2O5/NN-dimethylaniline/amine at 150 -190-degrees-C cyclization to mino-7H-pyrrolo[2,3-d]pyrimi-dine-5-carb onitriles, e.g. 5a and 5b, can be realized.