CLINICOPATHOLOGICAL, ENZYME AND HISTOCHEMICAL-STUDIES OF CENTROCYTIC (MANTLE CELL) LYMPHOMA - COMPARISON WITH OTHER TYPES OF LOW-GRADE B-CELL LYMPHOMA BASED ON THE UPDATED KIEL CLASSIFICATION
M. Takeshita et al., CLINICOPATHOLOGICAL, ENZYME AND HISTOCHEMICAL-STUDIES OF CENTROCYTIC (MANTLE CELL) LYMPHOMA - COMPARISON WITH OTHER TYPES OF LOW-GRADE B-CELL LYMPHOMA BASED ON THE UPDATED KIEL CLASSIFICATION, Acta Pathologica Japonica, 43(5), 1993, pp. 244-252
Lymph nodes from 21 cases of malignant lymphoma of a centrocytic (mant
le cell) type, (ML, cc (mc)) were examined. All the cases had monoclon
al surface immunoglobulin (sIg) M and/or D, but were negative for CD10
(CALLA), and CD11c (LeuM5). Lymphoma cells with CD25 (anti-Tac)+, CD5
(Leu1)+, and alkaline phosphatase (ALPase)- in eight cases showed bon
e marrow involvement (10-66% of the nucleated cells; mean 32 +/- 18%)
but with no leukemic changes. These eight cases had a similar phenotyp
e and were distributed by the lymphoma cells to the examined B-chronic
lymphocytic leukemia, Seven cases showed an infiltration of CD25-, CD
5+, and ALPase- lymphoma cells, in which only two cases showed focal b
one marrow involvement. There was a close relationship between CD25 ex
pression and bone marrow invasion by the lymphoma cells in ML, cc (mc)
. Three of the six CD25- and CD5- cases presented zonal proliferation
of ALPase+ lymphoma cells with round nuclei and a high anti-proliferat
ing cell nuclear antigen/cyclin (PCNA/c) rate in the mantle zone and p
aracortex, accompanied by a prominent interdigitating dendritic and hi
stiocytic cell reaction. Examined CD25-, CD5-and ALPase+ lymphoma show
ed a neoplastic counterpart of so-called marginal zone lymphocytes, wh
ich was different from other cases of ML, cc (mc). Lymphoma cells in M
L, cc (mc), except for those of the so-called marginal zone lymphoma,
might be derived from sigM+, D+/-, CD25+/-, CD5+/-, ALPase-, CD10- and
CD11c- lymphocytes present in the mantle zone and primary lymph folli
cles. Other types of low-grade B cell neoplasms that were examined had
different tumor cell markers for Ig, CD5, CD10, CD11c, a higher PCNA/
c rate, and prominent dendritic cells and histiocytic reaction when co
mpared with those of ML, cc (mc).