THE DEVELOPMENT OF A PREDICTIVE METHOD FOR THE ESTIMATION OF FLUX THROUGH POLYDIMETHYLSILOXANE MEMBRANES .4. APPLICATION TO A SERIES OF SUBSTITUTED QUINOLINES

The steady-state flux of 33 substituted quinoline derivatives was dete rmined in polydimethylsiloxane membranes using isopropyl alcohol as th e receiver solvent. These diffusants constituted a diverse group of co mpounds possessing a wide range of hydrophobic, steric, and electronic characteristics. Various parameters representing these physicochemica l properties such as cyclohexane-water fragmental constants, molar ref ractivity, Hammett's sigma constants, intramolecular hydrogen bonding ability, melting point, and mole fraction solubility were employed to develop empirical models capable of relating the rate of diffusion to these characteristics of either the substituent on the quinoline ring or the compound itself.