ANALYSIS OF MICELLE FORMATION OF AN ADRIAMYCIN-CONJUGATED POLY(ETHYLENE GLYCOL) POLY(ASPARTIC ACID) BLOCK-COPOLYMER BY GEL-PERMEATION CHROMATOGRAPHY

Authors
YOKOYAMA M SUGIYAMA T OKANO T SAKURAI Y NAITO M KATAOKA K
Citation
M. Yokoyama et al., ANALYSIS OF MICELLE FORMATION OF AN ADRIAMYCIN-CONJUGATED POLY(ETHYLENE GLYCOL) POLY(ASPARTIC ACID) BLOCK-COPOLYMER BY GEL-PERMEATION CHROMATOGRAPHY, Pharmaceutical research, 10(6), 1993, pp. 895-899
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Pharmaceutical research → ACNP
ISSN journal
07248741
Volume
10
Issue
6
Year of publication
1993
Pages
895 - 899
Database
ISI
SICI code
0724-8741(1993)10:6<895:AOMFOA>2.0.ZU;2-L
Abstract
The micelle-forming behavior of a drug-block copolymer conjugate {adri amycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copo lymer; PEG-P[Asp(ADR)]} was analyzed by gel permeation chromatography (GPC). Four compositions of the conjugates were observed to form micel lar structures in aqueous media, and their micelle-forming behavior wa s found to be dependent on the composition and media. These micelles d id not reach equilibrium within short time periods like low molecular weight surfactants. One composition formed stable micelles in the pres ence of serum.