TRICYCLIC ANTIDEPRESSANT PLASMA-LEVELS AFTER AUGMENTATION WITH CITALOPRAM - A CASE-STUDY

In a depressed patient, the addition of citalopram 40-60 mg per day to treatment with amitriptyline 75 mg per day had no effect on the plasm a levels of amitriptyline and nortriptyline, but it led to clinical im provement without the appearance of adverse effects. This and similar findings in four other patients comedicated with citalopram and amitri ptyline (2 patients), clomipramine or maprotiline suggest that citalop ram differs from other selective serotonin reuptake inhibitors, such a s fluvoxamine and fluoxetine, which have been shown to increase tricyc lic antidepressant plasma levels.