SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF GLYCYLGLYCINE SCHIFF-BASE COMPLEXES OF 3D TRANSITION-METAL IONS

Two new Schiff bases, N-4-hydroxysalicylidene-glycylglycine (K.GGRS.H2 O), N-O-vanillal-glycylglycine (K.GGVS.3H2O) and their manganese(II), cobalt(II), nickel(II) and copper(II) complexes have been synthesized and characterized by elemental analysis, t.g.a., molar conductance, i. r. and u.v. spectral studies. The C-13 n.m.r. spectrum of one of the S chiff base ligands has been recorded. The results show that the ligand is coordinated to the central metal ion via amide nitrogen, imino nit rogen, phenolic oxygen and carboxyl oxygen to form a quadridentate com plexes. Some of the complexes exhibit strong inhibitory action towards Candida albicans and Cryptococcus neoformans.