SAFETY AND EFFICACY OF LOMEFLOXACIN VERSUS NORFLOXACIN IN THE TREATMENT OF COMPLICATED URINARY-TRACT INFECTIONS

Seventy patients with complicated urinary tract infections were treate d with either lomefloxacin (400 mg once daily) or norfloxacin (400 mg twice daily) for 10 to 14 days. A total of 19 (86 %) of 22 patients tr eated with lomefloxacin and 20 (74 %) of 27 patients treated with norf loxacin were cured, as defined by a negative culture five to nine days after completion of therapy (p = 0.09). After four to six weeks, the figures were 56 % for lomefloxacin and 48 % for norfloxacin. Adverse e ffects in the lomefloxacin group were observed on 20 occasions in 12 p atients (one stopped treatment) compared to nine occasions in five pat ients treated with norfloxacin (difference not significant).