T. Miyamura et al., INTERACTION OF BCR-ABL WITH THE RETINOBLASTOMA PROTEIN IN PHILADELPHIA-CHROMOSOME-POSITIVE CELL-LINES, International journal of hematology, 65(2), 1997, pp. 115-121
The tyrosine kinase activity of BCR-ABL fusion proteins plays an impor
tant role in the pathogenesis of leukemia that is for the Philadelphia
chromosome (Ph(1)). Because nuclear c-ABL is regulated during the cel
l cycle through a specific interaction with the retinoblastoma protein
(pRB), the possible interaction of BCR-ABL with pRB in Ph(1)-positive
cell lines was investigated. P145 c-ABL as well as P190 and P210 BCR-
ABL proteins interacted with pRB. Furthermore, c-ABL and BCR-ABL assoc
iated with both phosphorylated and nonphosphorylated forms of pRB. The
se findings suggest that BCR-ABL interferes with pRB function and ther
eby regulates cell growth. (C) 1997 Elsevier Science Ireland Ltd.