HEMATURIA, HYPERESTROGENEMIA, AND HYPERPROGESTERONEMIA DUE TO A SERTOLI-CELL TUMOR IN A BILATERALLY CRYPTORCHID DOG

With a growth rate of up to 5-10 cm or more, Sertoli-cell tumors are t he most common cause of canine feminizing syndrome. In this study, an approximately 7-year-old, 29-kg Collie with an unknown long-term medic al history was presented for an acute episode of bleeding from the pen is. Following surgery, microscopic evaluation of testicular tissues co nfirmed the diagnosis of Sertoli-cell tumor of the left testicle and a trophy of the contralateral testicle. Cutaneous hyperpigmentation, gyn ecomastia, galactorrhea, a pendulous prepuce, attraction to other male s, and standing in a female position to urinate are signs commonly ass ociated with this syndrome. In the case presented, serum estradiol and progesterone levels returned to normal following removal of the Serto li-cell tumor, suggesting the endocrine imbalances evident in this cas e were directly due to this functional testicular neoplasm. The atroph y evident within the contralateral testicle also strongly suggests the functionality of the Sertoli-cell tumor. The patient in this case exh ibited the relatively uncommon finding of hematuria, which was conside red to be due to prostatitis secondary to endocrine-induced prostatome galy. Although lower on the list of differential diagnoses for hematur ia, one should consider Sertoli-cell tumor in cases of prostatomegaly of unknown origin in which the history of castration of the patient is unknown.