BRONCHIAL ASPERGILLOSIS AFTER FLUDARABINE THERAPY

Pulmonary aspergillosis is a common complication in neutropenic patien ts. The most important fungus is Aspergillus fumigatus. We report a ca se of invasive pulmonary aspergillosis due to Aspergillus nidulans sec ondary to fludarabine therapy. There are few cases of pulmonary asperg illosis due to Aspergillus nidulans (one chronic necrotizing pulmonary aspergillosis, one aspergilloma). Fludarabine induces a marked decrea sed of CD4 lymphocyte count responsible for opportunistic infections. It is the first case of aspergillosis after fludarabine therapy and th e occurrence of such infection must be considered after purine analog therapy.