DESIGN AND EVALUATION OF A NEW CENTRAL CORE MATRIX TABLET

In this paper, a study of the influence that two formulation variables exert on the drug release process from a new controlled drug delivery system has been realized in order to obtain a constant release rate d uring a prolonged period of time, and a programmed drug release. The d rug release profiles obtained for the different batches have shown an interesting relationship between the particle size of the channeling a gent used and the length of the zero-order periods. Furthermore, it is possible to modify the lag-times by using different granulometric fra ctions of the channeling agent. Similar results have been obtained by changing the weight of the assayed tablets. (C) 1997 Elsevier Science B.V.