The aim of this study was to investigate psychosocial influences and m
echanisms of coping to establish indications for psychotherapy in pati
ents with myasthenia gravis. We investigated clinical symptoms, person
ality, psychopathology, and coping in 44 patients with myasthenia grav
is. The patients' personalities were not characteristically altered, a
nd in 29.5% (13/44) of them, preexistent, long-term psychiatric distur
bances (according to International Classification of Diseases criteria
) were present, which corresponds to the prevalence in the average pop
ulation. In general, coping was characterized by an attitude of calmne
ss and acceptance, which is attributable to effective medical treatmen
t and could be considered an unspecific mode of coping with chronic di
seases of moderate severity. Four women had undergone psychotherapy be
cause of neurotic symptoms that were unrelated to myasthenia gravis. A
t the end of psychotherapy, their myasthenic symptoms had greatly impr
oved or disappeared. Psychotherapeutic techniques may be helpful in pa
tients with neurotic or reactive psychiatric symptoms, but there is no
general implication for psychotherapy in myasthenic patients, especia
lly if there is adequate ''somatic'' therapy.