DEGRADATION PATHWAY OF CARBOPLATIN IN AQUEOUS-SOLUTION

A degradation pathway for carboplatin in aqueous solution is described . Degraded solutions of carboplatin in water and in 5% glucose solutio n were analysed by high performance liquid chromatography; carboplatin and its degradation products were well separated. Three degradation p roducts of carboplatin have been determined either in pure water and 5 % glucose solution and they have been identified as 1,1-cyclobutanedic arboxilate anion, its protonated forms and cis-diamminediaquoplatinum (II) complex. (C) 1997 Elsevier Science B.V.