Development and implementation of a comprehensive program for safe han
dling of hazardous drugs is described. A comprehensive, multidisciplin
ary program for handling hazardous drugs was developed at a 1000-bed t
ertiary care, university teaching institution. Hazardous drugs were id
entified by a hazardous-drug working group consisting of occupational
health professionals, pharmacists, and an industrial hygienist. The Oc
cupational Safety and Health Administration (OSHA) 1986 handling guide
lines were used as a template, with input solicited from pharmacy staf
f and from other institutions. A new system for receiving, storing, an
d transporting hazardous drugs-which also included new labeling for su
ch drugs-was implemented. The new guidelines were discussed with the s
taff, with emphasis placed on absolute compliance and incorporation of
the guidelines into standard operating procedures and daily pharmacy
practices. All pharmacy employees underwent retraining to ensure compl
ete understanding. A voluntary medical surveillance program for pharma
cy employees was developed concomitantly to monitor exposure to genoto
xic hazardous drugs. Implementation of a comprehensive program for saf
e handling of hazardous drugs increased employee understanding of the
need for such a program and improved the hospital's compliance with re
cent OSHA regulations.