CARBAMAZEPINE COADMINISTRATION WITH FLUOXETINE OR FLUVOXAMINE

Authors
SPINA E AVENOSO A POLLICINO AM CAPUTI AP FAZIO A PISANI F
Citation
E. Spina et al., CARBAMAZEPINE COADMINISTRATION WITH FLUOXETINE OR FLUVOXAMINE, Therapeutic drug monitoring, 15(3), 1993, pp. 247-250
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy","Public, Environmental & Occupation Heath",Toxicology,Biology
Journal title
Therapeutic drug monitoring → ACNP
ISSN journal
01634356
Volume
15
Issue
3
Year of publication
1993
Pages
247 - 250
Database
ISI
SICI code
0163-4356(1993)15:3<247:CCWFOF>2.0.ZU;2-Z
Abstract
To study the potential interaction between carbamazepine (CBZ) and sel ective serotonin reuptake inhibitors, fluoxetine (20 mg/day) and fluvo xamine (100 mg/day) were administered for 3 weeks to eight and seven e pileptic patients, respectively, on chronic CBZ treatment. No signific ant changes in steady-state plasma concentrations of CBZ and its activ e metabolite, carbamazepine-10,11-epoxide (CBZ-E) occurred, suggesting that CBZ metabolism is probably not affected by fluoxetine or fluvoxa mine administration.