EFFECTS OF CHICKEN ANEMIA VIRUS ON MACROPHAGE FUNCTION IN CHICKENS

One-day-old chicks were inoculated intramuscularly with chicken anemia virus (CAV). Four birds were killed at 7, 14, 21, 28, and 42 days pos tinoculation (PI), and macrophages were recovered from spleen and bone -marrow suspensions. These were tested for interleukin-1 (IL-1) produc tion, Fc receptor expression, phagocytosis, and bactericidal activity. Macrophages recovered from uninoculated chickens at the same sample t imes, and exposed to CAV in vitro, were also tested. IL-1 production, Fc receptor expression, phagocytosis, and bactericidal activity were s ignificantly lower in all macrophage cultures from CAV-inoculated chic kens, and in cultures exposed to the virus in vitro, than in uninfecte d controls.