PROPHYLACTIC ENDOSCOPIC SCLEROTHERAPY OF ESOPHAGEAL-VARICES IN LIVER-CIRRHOSIS - LONG-TERM FOLLOW-UP AND FINAL RESULTS OF A MULTICENTER PROSPECTIVE CONTROLLED RANDOMIZED TRIAL IN VIENNA

This study reports the final results of a randomized multicenter trial on prophylactic endoscopic sclerotherapy of large esophageal varices in patients with liver cirrhosis. Forty-one patients received prophyla ctic treatment and 41 patients were in the control group. A first anal ysis 3 years after beginning the study revealed no significant differe nce in the distribution of the bleeding free intervals between both gr oups, but indicated a tendency towards longer survival of patients wit h prophylactic sclerotherapy. The follow-up of patients was continued for an additional 3 years. After this time, 53.7 % of patients in the sclerotherapy group and 39.1 % of patients in the control group were s till alive. During the study period of 6 years, variceal bleeding was observed in 31.7 % of patients in the sclerotherapy group and in 36.6 % of patients in the control group. Neither survival nor incidence of bleeding were statistically different between the two groups. The etio logy of cirrhosis did not influence the survival.