CARCINOEMBRYONIC ANTIGEN ISOTYPES IN TISSUE-SECTIONS AND LOOSE CYST FLUID CELLS OF OVARIAN NEOPLASMS

The aim of this study was to establish whether different subsets of ov arian neoplasms express a restricted isotype of carcinoembryonic antig en (CEA) which can be detected in solid tumors and detached cells. Six ty-one cases of mucinous, serous, endometrioid, and Krukenberg tumors were studied by immunohistochemistry using two monoclonal antibodies ( MAbs), commercial anti-CEA and D14 with a higher specificity for color ectal adenocarcinomas. The results with both antibodies showed a consi derable degree of heterogeneity between cases of nonserous tumors, wit h a more restrictive pattern observed with the D14 MAb. The proportion of immunostained cells was comparable in tumors and fluids.