A. Harlozinska et al., CARCINOEMBRYONIC ANTIGEN ISOTYPES IN TISSUE-SECTIONS AND LOOSE CYST FLUID CELLS OF OVARIAN NEOPLASMS, Tumor biology, 14(1), 1993, pp. 1-8
The aim of this study was to establish whether different subsets of ov
arian neoplasms express a restricted isotype of carcinoembryonic antig
en (CEA) which can be detected in solid tumors and detached cells. Six
ty-one cases of mucinous, serous, endometrioid, and Krukenberg tumors
were studied by immunohistochemistry using two monoclonal antibodies (
MAbs), commercial anti-CEA and D14 with a higher specificity for color
ectal adenocarcinomas. The results with both antibodies showed a consi
derable degree of heterogeneity between cases of nonserous tumors, wit
h a more restrictive pattern observed with the D14 MAb. The proportion
of immunostained cells was comparable in tumors and fluids.