EFFECTS OF 17-BETA-ESTRADIOL, PROGESTERONE AND TAMOXIFEN ON INVITRO PROLIFERATION OF HUMAN PITUITARY-ADENOMAS - CORRELATION WITH SPECIFIC CELLULAR RECEPTORS

Authors
CARONTI B PALLADINI G BEVILACQUA MG PETRANGELI E FRAIOLI B CANTORE G TAMBURRANO G CARAPELLA CM JAFFRAINREA ML
Citation
B. Caronti et al., EFFECTS OF 17-BETA-ESTRADIOL, PROGESTERONE AND TAMOXIFEN ON INVITRO PROLIFERATION OF HUMAN PITUITARY-ADENOMAS - CORRELATION WITH SPECIFIC CELLULAR RECEPTORS, Tumor biology, 14(1), 1993, pp. 59-68
Citations number
36
Categorie Soggetti
Oncology
Journal title
Tumor biology → ACNP
ISSN journal
10104283
Volume
14
Issue
1
Year of publication
1993
Pages
59 - 68
Database
ISI
SICI code
1010-4283(1993)14:1<59:EO1PAT>2.0.ZU;2-M
Abstract
Six human pituitary adenoma cultures, characterized for estrogen and p rogesterone (Pg) receptors, were treated with 17beta-estradiol (17beta -E2), Pg and tamoxifen (TAM) at different concentrations, alone and in combination, for 2, 4 and 8 days. Cell proliferation data showed in m ost cases a stimulating effect of 17beta-E2 and an inhibitory effect o f Pg on cell growth, which appeared to be correlated with specific rec eptor expression, but independent of pituitary cell hormone content. A marked inhibitory effect of TAM on cell proliferation was present in all cases, but, on the contrary, was independent of estrogen receptor expression.