OPTICAL RESOLUTION MECHANISMS OF UNICONAZOLE AND STRUCTURALLY RELATED-COMPOUNDS ON CYCLODEXTRIN-BONDED COLUMNS

Enantiomers of uniconazole have been separated by high-performance liq uid chromatography on a gamma-cyclodextrin-bonded column and the mecha nisms of the chiral recognition have been studied. From investigations on the retention and resolution of structurally related compounds of uniconazole on gamma-and beta-cyclodextrin columns the benzene ring an d alkyl group of the solute were found to play an important role in th e formation of the CD complex and in the chiral recognition. Nuclear m agnetic resonance data for the model systems of uniconazole and some a nalogs also supported these conclusions.