RESOLUTION OF RACEMIC MIXTURES OF HYOSCYAMINE AND COLCHICINE ON IMPREGNATED SILICA-GEL LAYERS

Authors
BHUSHAN R ALI I
Citation
R. Bhushan et I. Ali, RESOLUTION OF RACEMIC MIXTURES OF HYOSCYAMINE AND COLCHICINE ON IMPREGNATED SILICA-GEL LAYERS, Chromatographia, 35(9-12), 1993, pp. 679-680
Citations number
12
Categorie Soggetti
Chemistry Analytical
Journal title
Chromatographia → ACNP
ISSN journal
00095893
Volume
35
Issue
9-12
Year of publication
1993
Pages
679 - 680
Database
ISI
SICI code
0009-5893(1993)35:9-12<679:RORMOH>2.0.ZU;2-M
Abstract
The enantiomeric resolution of (+/-)-hyoscyamine (atropine) and (+/-)- colchicine was achieved on silica gel impregnated with an optically ac tive acid, L-aspartic acid (.03 %), as the chiral selector. The solven t system n-butanol chloroform acetic acid water (3:6:4:1, v/v), was fo und to resolve (+/-) mixtures.