Fifty-nine patients suffering from a major depressive episode, for who
m electroconvulsive therapy (ECT) was clinically indicated, were rando
mly assigned to one of three electrode placement groups for treatment
with brief pulse, threshold-level ECT: bitemporal (BT), right unilater
al (RU) or bifrontal (BF). Comparison of these groups in terms of numb
er of treatments, duration of treatment, or incidence of treatment fai
lure, showed that the bilateral placements were superior to the unilat
eral; comparison of Hamilton, Montgomery-Asberg, and visual analogue s
cale scores showed that the bifrontal placement was superior to both b
itemporal and unilateral treatment. Bitemporal treatment showed therap
eutic results intermediate between BF and RU. Because BF ECT causes fe
wer cognitive side effects than either RU or BT, and is independently
more effective, it should be considered as the first choice of electro
de position in ECT.