R. Fogelholm et K. Murros, CIGARETTE-SMOKING AND RISK OF PRIMARY INTRACEREBRAL HEMORRHAGE - A POPULATION-BASED CASE-CONTROL STUDY, Acta neurologica Scandinavica, 87(5), 1993, pp. 367-370
From September 1985 to December 1989 a total of 158 patients had prima
ry intracerebral haemorrhage in the population of 116000 in the Jyvask
yla Region, Central Finland. All had the diagnosis confirmed by either
computerised tomography or necropsy, and information on cigarette smo
king habits was available in 155 patients, 20% of whom were current ci
garette smokers. One control was selected for each of the 155 patients
matched on sex, age, and residence from the census of Central Finland
. The odds ratio of primary intracerebral haemorrhage of current cigar
ette smokers compared with current non-smokers was estimated on basis
of the number of discordant pairs as 1.4 (95% confidence interval 0.7
to 2.8). Adjustment for hypertension or diabetes did not change this e
stimate. Our data did not show evidence of an positive association of
cigarette smoking and risk of primary intracerebral haemorrhage. This
assumption was strenghtened when the results of previous studies and t
he present study were pooled giving an odds ratio of 1.0 (95% confiden
ce interval 0.8 to 1.3).