EFFECTS OF THE SESQUITERPENE CAPSIDIOL ON ISOLATED GUINEA-PIG ILEUM AND TRACHEA, AND ON PROSTAGLANDIN SYNTHESIS INVITRO

Authors
NASIRI A HOLTH A BJORK L
Citation
A. Nasiri et al., EFFECTS OF THE SESQUITERPENE CAPSIDIOL ON ISOLATED GUINEA-PIG ILEUM AND TRACHEA, AND ON PROSTAGLANDIN SYNTHESIS INVITRO, Planta medica, 59(3), 1993, pp. 203-206
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
59
Issue
3
Year of publication
1993
Pages
203 - 206
Database
ISI
SICI code
0032-0943(1993)59:3<203:EOTSCO>2.0.ZU;2-4
Abstract
The sesquiterpene capsidiol (1), isolated from elicited, cultured cell s of Nicotiana silvestris (1), inhibits contraction induced by the ago nists, histamine, acetylcholine, bradykinin, and barium chloride in th e isolated guinea-pig ileum. In addition, capsidiol inhibits contracti on induced by histamine and carbachol in the isolated guinea-pig trach ea in a nonspecific and non-competitive but concentration-dependent ma nner. Capsidiol also inhibits prostaglandin synthesis (cyclooxygenase) in vitro in a concentration dependent manner.