SPINAL OR SYSTEMIC ANALGESIA AFTER EXTENSIVE SPINAL SURGERY - COMPARISON BETWEEN INTRATHECAL MORPHINE AND INTRAVENOUS FENTANYL PLUS CLONIDINE

Study Objective: To compare two different methods of postoperative ana lgesia after extensive spinal fusion. Design: Double-blind, randomized study. Setting: University-affiliated hospital. Patients: Twenty four adult patients undergoing scoliosis correction. Interventions: Before the end of surgery, patients received either intravenous clonidine 0. 3 mug/kg/hr and fentanyl 25 mug/kg (after an hourly dose of clonidine 2.5 mug/kg) or intrathecal morphine 0.3 mg. A saline infusion was admi nistered to patients receiving morphine intrathecally. Measurements an d Main Results: Pain and sedation scores, hemodynamic data, and blood gases were collected in the recovery room at tracheal extubation and t hen every 2 hours for the next 14 hours. Tracheal extubation was perfo rmed at the same time in both groups (i.e., an average of 4 hours afte r the analgesic regimens were started). Intrathecal morphine provided a mean score of 20 mm on a visual analog scale ranging from 0 mm (no p ain) to 100 mm (severe pain), but it resulted in increased PaCO2 at ex tubation (44 +/- 7 mmHg) and 2 hours later (42 +/- 7 mmHg). PaCO2 was greater than 50 mmHg in four patients receiving intrathecal morphine. Fentanyl-clonidine resulted in equipotent analgesia but was accompanie d by sedation (sleeping but arousal by light tactile stimulation) and moderate hypotension (up to 69 +/- 9 mmHg for mean arterial pressure). Conclusions: This study shows that there is a major risk of respirato ry depression with a single intrathecal dose of morphine 0.3 mg to con trol postoperative pain after scoliosis surgery. Systemic clonidine-fe ntanyl may be a possible approach to the postoperative pain treatment of this surgery.