MODIFIED CARBON FLUX DURING OXYGEN LIMITED GROWTH OF CORYNEBACTERIUM-GLUTAMICUM AND THE CONSEQUENCES FOR AMINO-ACID OVERPRODUCTION

The amino acid producing bacterium Corynebacterium glutamicum accumula ted lactate, succinate and acetate under oxygen-limited growth conditi ons. Significant restructuring of carbon flux through the central meta bolic pathways occurred with a notable decrease in pentose pathway flu x and the operation of the TCA cycle in a reductive mode. Simultaneous consumption of residual sugar and organic acids took place when oxyge n sufficient conditions were restored though amino acids yields were s ignificantly perturbed.