A case of sphenoid sinusitis due to Pseudallescheria boydii is describ
ed in a 52-year-old non-immunocompromised woman. Treatment should alwa
ys involve surgical drainage, and antifungal chemotherapy may be of be
nefit if there is histological evidence of invasion of surrounding tis
sue. For P. boydii infection miconazole should be the agent of choice,
rather than amphotericin B. For this reason it is important to obtain
culture and histological examination of sinus contents if fungal infe
ction is suspected.