PARVOVIRUS B19-ASSOCIATED HEMOPHAGOCYTIC SYNDROME WITH LYMPHADENOPATHY RESEMBLING HISTIOCYTIC NECROTIZING LYMPHADENITIS (KIKUCHIS DISEASE)

Authors
YUFU Y MATSUMOTO M MIYAMURA T NISHIMURA J NAWATA H OHSHIMA K
Citation
Y. Yufu et al., PARVOVIRUS B19-ASSOCIATED HEMOPHAGOCYTIC SYNDROME WITH LYMPHADENOPATHY RESEMBLING HISTIOCYTIC NECROTIZING LYMPHADENITIS (KIKUCHIS DISEASE), British Journal of Haematology, 96(4), 1997, pp. 868-871
Citations number
12
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
96
Issue
4
Year of publication
1997
Pages
868 - 871
Database
ISI
SICI code
0007-1048(1997)96:4<868:PBHSWL>2.0.ZU;2-8
Abstract
A 15-year-old girl developed a haemophagocytic syndrome caused by huma n parvovirus B19 (PVB19). The cervical lymph node histology, resemblin g that of histiocytic necrotizing lymphadenitis (HNL, Kikuchi's diseas e), included several transformed lymphocytes, numerous histiocytes, an d massive necrosis. We detected PVB19-positive cells in the lymph node by immunohistochemistry. Possible autoimmune mechanisms in HNL-like d iseases triggered by PVB19 are discussed.