Y. Yufu et al., PARVOVIRUS B19-ASSOCIATED HEMOPHAGOCYTIC SYNDROME WITH LYMPHADENOPATHY RESEMBLING HISTIOCYTIC NECROTIZING LYMPHADENITIS (KIKUCHIS DISEASE), British Journal of Haematology, 96(4), 1997, pp. 868-871
A 15-year-old girl developed a haemophagocytic syndrome caused by huma
n parvovirus B19 (PVB19). The cervical lymph node histology, resemblin
g that of histiocytic necrotizing lymphadenitis (HNL, Kikuchi's diseas
e), included several transformed lymphocytes, numerous histiocytes, an
d massive necrosis. We detected PVB19-positive cells in the lymph node
by immunohistochemistry. Possible autoimmune mechanisms in HNL-like d
iseases triggered by PVB19 are discussed.