PATHOGENESIS OF ACANTHAMOEBIC KERATITIS - HYPOTHESIS BASED ON A HISTOLOGICAL ANALYSIS OF 30 CASES

Authors
GARNER A
Citation
A. Garner, PATHOGENESIS OF ACANTHAMOEBIC KERATITIS - HYPOTHESIS BASED ON A HISTOLOGICAL ANALYSIS OF 30 CASES, British journal of ophthalmology, 77(6), 1993, pp. 366-370
Citations number
33
Categorie Soggetti
Ophthalmology
Journal title
British journal of ophthalmology → ACNP
ISSN journal
00071161
Volume
77
Issue
6
Year of publication
1993
Pages
366 - 370
Database
ISI
SICI code
0007-1161(1993)77:6<366:POAK-H>2.0.ZU;2-U
Abstract
The results of a histopathological study of 30 cases of Acanthamoeba k eratitis are construed as indicating a four stage pathogenetic sequenc e: (1) initial infection, involving breaching of the surface epitheliu m; (2) keratocyte depletion by the invading trophozoites; (3) inflamma tory response mediated by neutrophil polymorphonuclear leucocytes; (4) stromal necrosis attributable to leucocytic activity.