Pretreatment with ginseng total saponin (GTS) reduced the magnitude of
the methamphetamine-induced dopamine (DA), 3,4-dihydroxyphenylacetic
acid (DOPAC), and homovanillinic acid (HVA) depletions. It is suggeste
d that GTS can, in part, prevent the methamphetamine-induced striatal
dopaminergic depletions.