M. Datta et al., STRUCTURE OF 6-AMINOBENZOFURAN-2-SULFONAMIDE - A TROPICALLY ACTIVE CARBONIC-ANHYDRASE INHIBITOR, Journal of crystallographic and spectroscopic research, 23(6), 1993, pp. 519-522
Crystals of the title compound are triclinic. Space group P1, a = 8.65
2(2), b = 5.184(2), c = 5.050(2) angstrom, alpha = 100.26(3)-degrees,
beta = 100.33(4)-degrees, gamma = 72.82(3)-degrees. The structure was
solved by direct methods and refined by a full-matrix, least-squares p
rocedure to R = 0.033 for 1168 observed [I > 2sigma(I)] reflections. T
he sulfonamide group is at a right angle to the benzofuran ring and th
e dihedral angle between the benzene and furan ring is 2.0(1)-degrees.
In the crystal packing the molecules are linked together by N - H . .
. O and N - H . . . N type hydrogen bonds arranging themselves in suc
h a way that there are alternate hydrophobic and hydrophilic regions e
xtended along the a-axis.