PRIMARY HEPATIC VIPOMA

A 35-yr-old male presented with a 3-yr history of voluminous watery di arrhea. He had episodes of severe generalized weakness which responded to fluid and electrolyte replacement therapy. Investigations revealed a solitary liver mass and an elevated vasoactive intestinal polypepti de level. An extensive work-up did not show any other extrahepatic pri mary lesion. Surgical resection ameliorated all of his symptoms, accom panied by a decrease in the vasoactive intestinal polypeptide level. W e believe that this patient represents a case of primary hepatic vipom a syndrome. To our present knowledge, this has not been reported previ ously. We discuss the clinical manifestations, investigations, and man agement of the case.