DIPYRONE INTERFERENCE ON SEVERAL COMMON BIOCHEMICAL TESTS

We studied the effect in vitro and in vivo of dipyrone on the determin ation of several biochemical tests in two analyzers, a Hitachi 747 and a Kodak Ektachem 700. From studies in vitro, we found significant int erference by dipyrone (P < 0.05) in the determination of creatine kina se (CK), lactate dehydrogenase (LD), uric acid, triglycerides, cholest erol, aspartate aminotransferase, alanine aminotransferase, and urea n itrogen with both instruments, and in the determination of creatinine in the Ektachem analyzer. We also studied the effect of intravenously administered dipyrone in 14 patients. Dipyrone interfered significantl y (P < 0.05) in the determination of CK LD, uric acid, triglycerides, and cholesterol with both instruments, and creatinine only with the Ek tachem analyzer. Using high-performance liquid chromatography (HPLC), we measured concentrations of dipyrone in the serum of patients who ha d received the drug and observed a negative correlation between the co ncentrations of dipyrone in the blood and the percentage of each analy te concentration.