Considering the scientific and technological developments of the Healt
h Sector in Brazil, the area of generation of knowledge on endemic dis
eases is recognized as relevant priority. The assessment of the relate
d lines for Research and Development (R&D) constitutes the basis for d
escribing immediate perspectives and priorities. Analysis is proceeded
in two distinct and complementary levels. at first, basic epidemiolog
ic characteristics and Health Services demands are reviewed, later sci
entific and technological difficulties are identified. The studied end
emics are Malaria, South American Trypanosomiasis, Leishmaniasis, Schi
stosomiasis, Yellow Fever, Rabies and Filariasis.