Az. Maksyutov et Es. Zagrebelnaya, ADEPT - A COMPUTER-PROGRAM FOR PREDICTION OF PROTEIN ANTIGENIC DETERMINANTS, Computer applications in the biosciences, 9(3), 1993, pp. 291-297
ADEPT, a program that can be used for prediction of protein antigenic
determinants from the amino acid sequence alone for the cases of humor
al and cellular immune response, is described. Most methods presently
utilized for this purpose are implemented in the program along with so
me original parameters for the case of humoral immune response. There
is also a possibility to combine several methods for the case of humor
al immune response, which provides a means to create new predictive me
thods. ADEPT also includes a literature-derived database of proteins i
n the SWISS-PROT standard with experimentally determined antigenic det
erminants, so the predictive ability of new methods can be assessed wi
thin the program and corresponding statistical information is calculat
ed ADEPT may be useful for solving various tasks involving the delinea
tion of antigenic regions on proteins or characterization of peptide f
ragments, arising, for example, in protein engineering (e. g. selectio
n of protein portions most suitable for insertion of peptide sequences
that are antigenically active or possessing other desired characteris
tics), and in particular for construction of vaccines containing B- an
d/or T-cell epitopes, as well as for other problems of medico-biologic
al research.