MODIFIED METHOD FOR TESTING THE IMMUNOGENIC POTENCY OF RABIES VACCINES

To determine the immunogenic potency of different rabies vaccines, the y were tested in the modified test, originally developed by the Nation al Institutes of Health (USA). In this modification the mice used in t he test were challenged with strains Vnukovo-32 and Moskva instead of strain CVS, and the vaccine was introduced not in two injections, but in a single injection. The study revealed that the use of test strain Vnukovo-32, homologous to the production vaccine strain, enhanced the absolute potency of vaccines but produced no effect on the relative po tency when used with the similarly prepared reference agents. A single injection of the vaccine in the test for immunogenic potency was foun d to produce no changes in the results of tests for relative immunogen ic potency. However, this modification needs further more extensive tr ials and discussion.