MODIFIED METHOD FOR TESTING THE IMMUNOGENIC POTENCY OF RABIES VACCINES

Citation
Em. Tsetlin et Ln. Romanova, MODIFIED METHOD FOR TESTING THE IMMUNOGENIC POTENCY OF RABIES VACCINES, Zurnal mikrobiologii, epidemiologii i immunobiologii, (2), 1993, pp. 84-88
Citations number
8
Categorie Soggetti
Microbiology,Immunology,"Public, Environmental & Occupation Heath
ISSN journal
03729311
Issue
2
Year of publication
1993
Pages
84 - 88
Database
ISI
SICI code
0372-9311(1993):2<84:MMFTTI>2.0.ZU;2-#
Abstract
To determine the immunogenic potency of different rabies vaccines, the y were tested in the modified test, originally developed by the Nation al Institutes of Health (USA). In this modification the mice used in t he test were challenged with strains Vnukovo-32 and Moskva instead of strain CVS, and the vaccine was introduced not in two injections, but in a single injection. The study revealed that the use of test strain Vnukovo-32, homologous to the production vaccine strain, enhanced the absolute potency of vaccines but produced no effect on the relative po tency when used with the similarly prepared reference agents. A single injection of the vaccine in the test for immunogenic potency was foun d to produce no changes in the results of tests for relative immunogen ic potency. However, this modification needs further more extensive tr ials and discussion.