USE OF STREPTOCOCCAL IMMUNOGLOBULIN FC-RECEPTORS IN THE TECHNOLOGY OFTHE PRODUCTION OF A PSEUDOTUBERCULOSIS DIAGNOSTIC ASSAY SYSTEM

The conditions of obtaining the IgM from hyperimmune sera to Yersinia pseudotuberculosis have been established. The process includes the ads orption of these sera by streptococci belonging to serological groups G and A and having receptors which bind the Fc-fragment of IgG and IgA molecules. The data confirming the fact that specific antibodies to Y . pseudotuberculosis belong to IgM have been obtained. The use of isol ated IgM fractions for the preparation of a pseudotuberculosis diagnos tic assay system has made it possible to establish that the new method of obtaining sensitin is economical and ensured a 3.5-golf greater yi eld of the conjugate and simplifies the technological cycle of its pre paration.