SOME ASPECTS OF RELATIONS BETWEEN BETA-ADRENOCEPTORS AND HUMORAL-FACTORS IN CORONARY HEART-DISEASE

To assess the humoral regulation of beta-adrenoceptors (beta-AP) in co ronary heart disease, the lymphocyte receptor number (B(m)) and dissoc iation constant (K(d), ligand-I-125-cyanopindolol) as well as blood pl asma levels of epinephrine (E), norepinephrine (NE), cortisol, insulin (INS) and lipids were studied in 68 subjects aged 25-55. Three groups of persons were formed by the data of coronaroangiography and 210Tl m yocardial imaging maximal stress test: without coronary stenosis (cont rol group, n = 31), lower than 60% stenosis (n = 17) and higher than 6 0% stenosis (n = 20). The results obtained have shown that stenosis of coronary artheries itself has no effect on the binding parameters of lymphocyte beta-AP. In contrast, the values of both B(m) and K(d) were dependent on the body humoral status. This suggests that E regulated B(m) positively and NE negatively. INS and high density lipoprotein ch olesterol are possibly related with the K(d) values through the influe nce on cell membrane fluidity.