Vv. Chupin et al., P-31 NMR-STUDY OF MEMBRANE-STRUCTURE OF A LKYL PHOSPHATIDYLCHOLINE AND ITS LYSO-DERIVATIVES, Biologiceskie membrany, 10(2), 1993, pp. 204-211
Membrane structure and conformation of the phosphatidylcholine group o
f -O-hexadecyl-2-palmitoyl-rac-glycerophosphocholine (1), 1-O-hexadecy
l-sn-glycerophosphocholine (2), 1,2-di-O-hexadeecylyden-sn-glycerophos
phocholine (3) and 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (pl
atelet activating factor) (4) have been investigated by P-31 NMR. It h
as been shown that phospholipids (1-4) form bilayer structures under c
onditions of incomplete hydration. Lysophosphatidylcholine (2) and its
structural analogues (3, 4) formed micelles in the excess of water. A
nisotropy of the chemical shift of phospholipids (1, 3, 4) was more th
an two times greater as compared with lysophosphatidylcholine (2) in g
el and liquid crystalline phase. The reason is the absence of fast rot
ation around the C1-C2 bond of the glycerol residue of phospholipids (
1, 3, 4).