BASE-CATALYZED DEGRADATIONS OF RAPAMYCIN

Authors
STEFFAN RJ KEARNEY RM HU DC FAILLI AA SKOTNICKI JS SCHIKSNIS RA MATTES JF CHAN KW CAUFIELD CE
Citation
Rj. Steffan et al., BASE-CATALYZED DEGRADATIONS OF RAPAMYCIN, Tetrahedron letters, 34(23), 1993, pp. 3699-3702
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
23
Year of publication
1993
Pages
3699 - 3702
Database
ISI
SICI code
0040-4039(1993)34:23<3699:BDOR>2.0.ZU;2-C
Abstract
The base catalyzed degradation of rapamycin was re-examined and a sequ ence of steps involving beta-elimination, retro-aldol cleavage and ben zilic acid rearrangement occur leading to several new products.