SYNTHESIS OF LIPOPHILIC AND FLUORESCENT DERIVATIVES OF N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE

Synthesis of lipophilic derivatives of N-acetylmuramyl-L-alanyl-D-isog lutamine (MDP) by condensation of the C-terminal amino acid moiety in MDP molecule with phosphatidylethanolamine was carried out. Fluorescen t lipophilic derivatives of MDP were synthesized by condensation of MD P with phosphatidylethanolamines labelled in the hydrophobic moiety, e . g. pyrenyl)stearoyl]-sn-glycero-3-phosphoethanolamine and pyrenylpho sphatidylethanolamine.