Vv. Chudinova et al., P-31 NMR-STUDY OF THE INTERACTION OF ALPHA-TOCOPHEROL WITH PHOSPHOLIPIDS, FATTY-ACIDS AND THEIR OXYGENATED DERIVATIVES, Bioorganiceskaa himia, 19(2), 1993, pp. 243-249
Interaction of alpha-tocopherol with phospholipids, oleic, ricinoleic
acids and linoleic acid hydroperoxides was investigated by means of P-
31 NMR spectroscopy on a model artificial membranes containing egg pho
sphatidylcholine and lysophosphatidylcholine. Alpha-tocopherol was sho
wn to support the bilayer organization. of lisophospholipids, whereas
its introduction into the lecithine-water system stimulated the hexago
nal phase formation. Free fatty acids exhibited a synergism to alpha-t
ocopherol, the effect of the hexagonal phase formation being at most i
ncreased by oxygenated acids - ricinoleic acid and linoleic acid hydro
peroxides. In accordance with the experimental data, a conclusion abou
t modifying and structuring action of alpha-tocopherol was made. Origi
n of the alpha-tocopherol's modulating effect on the membrane structur
e and a possible, role of hexagonal phase forming upon its action in t
he course of peroxidation of lipids was discussed.