A method for preparing natural acetal phospholipids (1,2-alkylidene-sn
-glycero-3-phosphates) containing palmitic and oleic aldehyde residues
was suggested. The method involves the condensation of the aldehydes
with sn-glycero-3-phosphocholine and the enzymatic hydrolysis of the i
ntermediate 1,2-alkylidene-sn-glycero-3-phosphocholines with phospholi
pase D.