SYSTEMIC THERAPY OF DIFFUSE EFFLUVIA AND HAIR STRUCTURE LESIONS

A controlled randomized double-blind study was carried out in 72 femal e patients to compare tolerance and efficacy of two therapeutic agents containing vitamins of the B-group and L-cystine in different composi tions versus a placebo in diffuse effluvia and hair structure lesions. Hair swelling as a criterion of hair quality and frontal and parietal anagen rates in trichograms as criteria of hair growth were determine d before and after 4 months of therapy. Treatment with active medicati on 1 was statistically significantly superior to treatment with the pl acebo according to these criteria. Treatment with active medication 2 was superior to treatment with the placebo but inferior to treatment w ith active medication 1. The overall evaluation of efficacy by investi gator and patient was in good agreement with these results. The additi onal active ingredients contained in active medication 1 but not conta ined in active medication 2 contribute to the efficacy of the medicati on. They cannot be compensated by the higher amounts Of L-cystine cont ained in active medication 2. Given their good tolerance, no adverse e ffects were observed with the two active medications.