QUANTITATION OF NIZATIDINE IN CAPSULES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

A stability-indicating high-performance liquid chromatography method f or the quantitation of nizatidine in capsules has been developed. The method is accurate and precise with a percent relative standard deviat ion of 0.34 based on 6 readings. A number of inactive ingredients pres ent in the capsules did not interfere in the assay procedure. The reco very from the synthetic mixtures was quantitative. The extraction proc edure from the capsules is very simple. The drug appears to be very se nsitive to bases (such as sodium hydroxide) since 100% of the drug dec omposed on boiling for 35 minutes. The drug was very stable when boile d with sulfuric acid.