PROPHYLACTIC APPLICATION OF PROPIONIBACTERIUM-AVIDUM KP-40 IN SWINE WITH ACUTE EXPERIMENTAL INFECTIONS .2. BACTERIAL-INFECTIONS - PLEUROPNEUMONIA AND SWINE ERYSIPELAS

The potent immunomodifyer Propionibacterium avidum KP-40 (PA) demonstr ated prophylactic potency in swine infected experimentally with Haemop hilus (Actinobacillus) pleuropneumoniae or Erysipelothrix rhusiopathia e. Animals received PA either together with the respective vaccine or PA only; 3 resp. 4 weeks later all animals were inoculated with virule nt pathogens. Eight of 10 swine immunized with inactivated pleuropneum onia vaccine developed mild-moderate forms of infection with temporary stagnation of body weight; application of the vaccine together with P A lowered the morbidity rate to 1 of 10 (p<0.05). Also in non-vaccinat ed swine infected with pleuropenumonia or erysipelas PA application re sulted in milder clinical symptoms, faster recovery and a larger gain of body weight.