Post-extubation atelectasis (PEA) constitutes the commonest cause of l
ung collapse in ventilated neonates. The clinical and radiological fea
tures of 47 ventilated infants who developed PEA within 24 h of extuba
tion are reported. Three main radiographic patterns of atelectasis wer
e identified: (1) transient unilobar collapse resolving within 12 h of
extubation (19 cases), (2) multilobar atelectasis developing over a 4
8-h period (18 cases), and (3) progressive atelectasis resulting in co
mplete collapse of a whole lung. A similar number of ventilated infant
s without PEA served as controls. We found a significant association b
etween the incidence of PEA and multiple intubation (P < 0.02), presen
ce of patent ductus arteriosus (P < 0.001) and neonatal sepsis (P < 0.
05). Prophylactic physiotherapy is recommended for ventilated infants,
particularly those with the above risk factors.