A total of 104 patients with bilateral polycystic ovaries (PCO) diagno
sed by transvaginal ultrasound were classified into four groups (A < 5
cysts, B 5 - 10 cysts, C > 10 cysts located under ovarian capsule, D
numerous cysts distributed all over the ovary) according to the number
of microcysts. Ovarian volume, clinical features (menstrual disturban
ce, obesity and hirsutism), endocrine levels [luteinizing hormone (LH)
, LH/follicle stimulating hormone ratio, testosterone, andro-stenedion
e and dehydroepiandrosterone-sulphatel and response to clomiphene were
compared for each group and 17 control subjects with normal ovulatory
cycles. Ovarian volume in PCO subjects was significantly larger than
that in control subjects. As the number of microcysts increased, the o
varian volume enlarged and the endocrine abnormality worsened. All end
ocrine parameters in PCO subjects with menstrual disturbances were sig
nificantly higher than those in PCO subjects without menstrual disturb
ances and controls. In PCO subjects without menstrual disturbances onl
y andro-stenedione was significantly higher than in controls. Among PC
O subjects, the frequency of menstrual disturbances, the percentage of
response to clomiphene and the pregnancy rate in groups C and D were
significantly higher than in groups A and B. Therefore, screening the
ovaries in infertile patients by means of transvaginal ultrasound and
subsequent assessment of morphology in PCO may suggest endocrine abnor
mality and help in selecting the proper treatment.