COCAINE-MEDIATED DISRUPTION OF MICROFILAMENT INTEGRITY WITHIN NEURAL-FOLD NEUROEPITHELIAL CELLS OF CHICK-EMBRYOS CULTURED INVITRO

Authors
BROWN KM BURIN GJ
Citation
Km. Brown et Gj. Burin, COCAINE-MEDIATED DISRUPTION OF MICROFILAMENT INTEGRITY WITHIN NEURAL-FOLD NEUROEPITHELIAL CELLS OF CHICK-EMBRYOS CULTURED INVITRO, Toxicology in vitro, 7(3), 1993, pp. 285
Citations number
28
Categorie Soggetti
Toxicology
Journal title
Toxicology in vitro → ACNP
ISSN journal
08872333
Volume
7
Issue
3
Year of publication
1993
Database
ISI
SICI code
0887-2333(1993)7:3<285:CDOMIW>2.0.ZU;2-0
Abstract
The effects of cocaine on microfilaments within neuroepithelial cells of neurula-stage chick embryos cultured in vitro were investigated by an actin indirect immunofluorescence procedure. Results of this study suggest that the cocaine-induced inhibition of neural-fold closure in chick embryos cultured in vitro reported previously is mediated by a l oss of microfilament integrity within the neuroepithelium.